Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk.
نویسندگان
چکیده
Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.
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ورودعنوان ژورنال:
- Haematologica
دوره 92 5 شماره
صفحات -
تاریخ انتشار 2007